Mini research paper on breast cancer
Interestingly, 'compensatory' induction of alternative signal transduction is a phenomenon shared by other types of anti-cancer therapy, including anti-growth factors, chemotherapy and radiotherapy [ 77 - 79 ].
Causes of breast cancer
Effectively predict therapeutic response with growth inhibitors. Individualisation of therapies could be improved. This will be helped considerably by generating an atlas of mammary gland development. As the science improves, risk models can also help guide future research investments and policy decisions for population-level interventions. Footnotes The authors report no conflicts of interest in this work. Mammograms which involve breast irradiation are offered on an annual basis to women over 50 years in spite of controversy about their effectiveness, the anxiety caused by false positives, and the potential risks of radiation exposure in sensitive individuals. More recent studies with another class of drugs called aromatase inhibitors exemestane and anastrozole have shown that these drugs are also very effective in preventing breast cancer Other clinical trials are looking at non-hormonal drugs for breast cancer reduction. The need to understand not only the cancer, but the tumour microenvironment and patient characteristics including drug metabolism and immune mechanisms. Mothersill C, Seymour C. Even with the technology and medicine we have today to treat this deadly disease, the pain a patient experiences with breast cancer is still relentless. This work will probably also require targeted mechanistic and pharmacokinetic studies to assess appropriate dosing levels in test protocols to better address human exposure circumstances, including the influence of life stage, genetic variability, and multiple chemical exposures. However, hereditary factors are considered the major determinant of individual in risk.
This could explain the links between smoking and cancers not directly linked to the respiratory tract, but would also indicate there may be links, although not necessarily causative, with birth control pills. Recommendation Breast cancer researchers and research funders should support efforts to 1 develop statistical methodology for the estimation of risk of breast cancer for given sets of risk factors and that takes the life course perspective into account, 2 determine the proportion of the total temporal and geographic differences in breast cancer rates that can be plausibly attributed to established risk factors, and 3 develop modeling tools that allow for calculation of breast cancer risk, in both absolute and relative terms, with the goal of assessing potential risk reduction strategies, at both personal and public health levels.
Tria Tirona M.
Origin of breast cancer
It is now known that breast cancer can be divided into subtypes that respond differently to various types of treatment. The paper is structured as follows: What are our fundamental beliefs and are they valid? Few reliable estimates of these temporal and international differences in risk factor prevalence exist. Slowing the increase in the population dose resulting from CT scans. In addition we also lack understanding of how tumour cells suppress the immune response to ensure their survival and growth. Generate new, targeted therapies based on target discovery. Keywords: breast cancer, causes, treatment, questioning paradigms Background There is a perception that cancer research generally, and breast cancer research specifically, is not progressing as fast as might be hoped from the investment in research. A new theory on the cancer-inducing mechanism. The NCI-funded Detroit Research on Cancer Survivors Detroit ROCS study will look at the major factors affecting cancer progression, recurrence, mortality, and quality of life among African-American survivors of four different cancers, including breast. Stem cells The recent development of technologies allowing enrichment of mammary gland stem cells has been a significant step forward [ 19 , 20 , 35 ]. Positive suggestions to move forward It is easy to criticize, but necessary to suggest possible solutions. Beyond mammography: new frontiers in breast cancer screening. ResearchGate, doi Better genetic risk estimation.
These circulating tumor cells CTCs can be detected with sensitive lab tests. Thus, breastfeeding contributes to the health of both mother and child. Improved research reagents Better research reagents are needed to continue to accurately define new pathways in experimental material and to study clinical samples to verify these pathways as biomarkers in relation to pathology and outcome.
The Confluence Projectfrom NCI's Division of Cancer Epidemiology and Geneticswill develop a research resource that includes data from thousands of breast cancer patients and controls of different races and ethnicities.
based on 66 review